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Bioinformatics Seminar

Thursday , September 11,  4:15pm,  Toxicology Auditorium
Speaker:Dr. Ganesh Ganapathy, Postdoctoral Fellow, National Evolutionary Synthesis Center
Title:Human-Chimpanzee-Gorilla ancestral population genomics with an explicit model of the coalescent with recombination.
Abstract:We use an explicit model of recombination to derive closed-form expressions for how recombination changes the gene tree along an alignment of human, chimp, gorilla genomes. We incorporate the derived expressions into the hidden-Markov-model (HMM) framework of Hobolth et. al (2006, PLoS Genetics) and estimate the human-chimp and human-chimp-gorilla speciation times and ancestral effective population sizes.

Joint work with Marcy Uyenoyama, Julien Dutheil, Asger Hobolth, Mikkel Schierup and Thomas Mailund.
Page last updated: March 22, 2005

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